期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 38, 期 7, 页码 1833-1838出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/eji.200838511
关键词
autoimmunity; EAE; IL-21; myocarditis; Th17
类别
Th17 cells have been recognized as the central effectors in organ-related autoimmune diseases. IL-6 is a key factor that reciprocally regulates Th17 and Foxp3(+) Tyeg differentiation by inhibition of TGF-P induced Foxp3 and induction of RORyt, a Th17 lineage-specific transcription factor. Recently IL-21 has been suggested to induce RORyt and Th17 development in the absence of IL-6. However, the relevance of IL-21 for Th17-dependent inflammatory responses in uiuo remains unclear. In this study, we demonstrate that differentiation of IL-17-producing CD4 T cells, their recruitment to inflamed organs, and the development of autoimmune disease was not affected in il21R(-/-) and il21(-/-) mice in models of myelin oligodendrocyte glycoprotein-induced autoimmune encephalitis and autoimmune myocarditis. IL-6 induced Th17 differentiation independent of and much more potently than IL-21 in uitro. These data suggest that IL-6 is sufficient to drive Th17 development and associated autoirnmunity in uiuo in the absence of IL-21 or IL-21R.
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