期刊
ACS NANO
卷 9, 期 8, 页码 7874-7885出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.5b02843
关键词
vesicles; stimuli-responsive release; cancer imaging; photothermal therapy; synergistic effect
类别
资金
- National Natural Science Foundation of China [31422021, 51473109, 81202472, 21074081, 21274096]
- National Basic Research Program of China [2012CB932500, 2014CB931903]
- Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions
- Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases [BM2013003]
Smart nanocarriers are of particular interest as nanoscale vehicles of imaging and therapeutic agents in the field of theranostics. Herein, we report dually pH/reduction-responsive terpolymeric vesicles with monodispersive size distribution, which are constructed by assembling acetal- and disulfide-functionalized star terpolymer with near-infrared cyanine dye and anticancer drug. The vesicular nanostructure exhibits multiple theranostic features including on-demand drug releases responding to pH/reduction stimuli, enhanced photothermal conversion efficiency of cyanine dye, and efficient drug translocation from lysosomes to cytoplasma, as well as preferable cellular uptakes and biodistribution. These multiple theranostic features result in ultrahigh-contrast fluorescence imaging and therrno-chemotherapy-synergized tumor ablation. The dually stimuli-responsive vesicles represent a versatile theranostic approach for enhanced cancer imaging and therapy.
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