期刊
EUROPEAN JOURNAL OF HUMAN GENETICS
卷 16, 期 6, 页码 762-765出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ejhg.2008.4
关键词
ethnicity; race; population structure; socioeconomic status; DENV3
资金
- NIAID NIH HHS [R21 AI056263, R21 AI 056263] Funding Source: Medline
To test whether African ancestry is protective for severe dengue, we genotyped 49 hospitalized cases of dengue hemorrhagic fever (DHF) as well as 293 neighborhood cases of dengue fever and 294 asymptomatic controls in Salvador, Bahia, Brazil. Ancestry-informative markers and 282 unlinked SNPs not associated with the clinical presentation of dengue were used to estimate ancestry. After controlling for income, both self-defined Afro-Brazilian ethnicity and African ancestry were protective for DHF (P = 0.02, OR = 0.28 and P = 0.02, OR = 0.13, respectively). Income or an index of income indicators, however, was also independently associated with the diagnosis of DHF.
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