期刊
EUROPEAN JOURNAL OF HUMAN GENETICS
卷 17, 期 3, 页码 383-386出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ejhg.2008.182
关键词
SNP; sequencing
Resequencing of genomic regions that have been implicated by linkage and/or association studies to harbor genetic susceptibility loci represents a necessary step to identify causal variants. Massively parallel sequencing (MPS) offers the possibility of SNP discovery and frequency determination among pooled DNA samples. The strategies of pooling DNA samples and pooling PCR amplicons generated from individual DNA samples were evaluated, and both were found to return accurate estimates of SNP frequencies across varying levels of sequence coverage.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据