期刊
EUROPEAN JOURNAL OF HEART FAILURE
卷 12, 期 8, 页码 767-778出版社
WILEY
DOI: 10.1093/eurjhf/hfq120
关键词
Peripartum cardiornyopathy; Definition
资金
- South African National Research Foundation
- German Research Foundation, DFG [HI/842/6-1]
- Heart Failure Association of the European Society of Cardiology
Peripartum cardiomyopathy (PPCM) is a cause of pregnancy-associated heart failure. It typically develops during the last month of, and up to 6 months after, pregnancy in women without known cardiovascular disease. The present position statement offers a state-of-the-art summary of what is known about risk factors for potential pathophysiological mechanisms, clinical presentation of, and diagnosis and management of PPCM. A high index of suspicion 15 required for the diagnosis, as shortness of breath and ankle swelling are common in the peripartum period. Peripartum cardiomyopathy is a distinct form of cardiomyopathy, associated with a high morbidity and mortality, but also with the possibility of full recovery. Oxidative stress and the generation of a cardiotoxic subfragment of prolactin may play key roles in the pathophysiology of PPCM. In this regard pharmacological blockade of prolactin offers the possibility of a disease-specific therapy.
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