期刊
EUROPEAN JOURNAL OF HEART FAILURE
卷 10, 期 10, 页码 997-1000出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejheart.2008.07.001
关键词
Chronic heart failure; Renal function; Albuminuria; Tubular damage; NGAL; Neutrophil gelatinase associated lipocalin
资金
- The Netherlands Heart Foundation [200613157, 2006T37, D97017]
Renal impairment, as measured by reduced glomerular filtration rate (GFR) and increased urinary albumin excretion (UAE), is prevalent in patients with chronic heart failure (CHF) and is associated with reduced survival. The prevalence of structural tubular damage in CHF is unknown. We investigated 90 CHF patients and 20 age and sex matched healthy controls, and determined estimated GFR, UAE, N terminal-pro brain natriuretic peptide (NT-proBNP) and urinary neutrophil gelatinase associated lipocalin (NGAL) as a marker for tubular damage. CHF patients had significantly lower averaged estimated GFR (64 +/- 17 vs 90 +/- 12 mL/min/1.73 m(2), P < 0.0001), but higher NT-proBNP and UAE levels (both P < 0.0001). Median urinary NGAL levels were markedly increased in CHF patients compared to controls (175 (70-346) vs 37 (6-58) mu g/gCr, P < 0.0001). Both serum creatinine (r=0.26, P=0.006) and eGFR (r=-0.29, P=0.002) were significantly associated with urinary NGAL levels as were NT-proBNP and UAE but to a lesser extent. In conclusion, renal impairment in CHF patients is not only characterised by decreased eGFR and increased UAE, but also by the presence of tubular damage, as measured by increased urinary NGAL concentrations. (c) 2008 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
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