期刊
EUROPEAN JOURNAL OF HEART FAILURE
卷 10, 期 8, 页码 772-779出版社
OXFORD UNIV PRESS
DOI: 10.1016/j.ejheart.2008.06.009
关键词
acute heart failure; troponin I; troponin T; prognosis
资金
- Finnish Foundation for Cardiovascular Research
- Paulo Foundation
- Orion Pharma
- Kanta-Hame Central Hospital Research fund
Background: Elevated cardiac troponin (cTn) levels are relatively common in acute heart failure(AHF). Aims: To evaluate the prevalence and prognostic significance of elevated cTnI and cTnT in AHF. Methods: FINN-AKVA is a prospective, multicenter study in AHF. In this analysis, 364 non-ACS patients with measurements of cTnI and cTnT taken on admission and 48 h thereafter were analyzed. Results: Of the 364 AHF patients, 51.1% had cTnI and 29.7% cTnT levels above the cut-off value. Six-month all-cause mortality was 18.7%. Both cTnI (OR 2.0, 95% CI 1.2-3.5 p=0.01) and cTnT (OR 2.6, 95% CI 1.5-4.4, p=0.0006) were associated with adverse outcome. The mortality risk was proportional to the magnitude of cTn release. On multivariable analysis, Cystatin C (OR 6.3, 95% CI 3.2-13, p < 0.0001), logNT-proBNP (OR 1.4, 95% CI 1.0-1.8, p= 0.03) and systolic blood pressure on admission (/10 mm Hg increase, OR 0.9, 95% CI 0.8-0.9, p=0.0004) were independent risk markers, whereas the troponins were not significantly associated with increased mortality. Conclusions: cTn elevations are frequent in AHF patients without ACS. cTnI is more often elevated than cTnT. Both cTnI and cTnT elevations are associated with increased mortality proportional to the degree elevation but they do not act as independent risk markers. (C) 2008 European Society of Cardiology. Published by Elsevier B. V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据