期刊
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
卷 23, 期 9, 页码 787-793出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MEG.0b013e32834902dd
关键词
Barcelona Clinic Liver Cancer stage B; hepatocellular carcinoma; prognostic value; serum gamma-glutamyl transferase; transcatheter arterial embolization chemoembolization
资金
- National Natural Science Foundation of China
- Research Grants Council [30872505]
- Research Fund for the Doctoral Program of Higher Education of China [200802461037]
Objectives Not every unresectable hepatocellular carcinoma (HCC) could receive survival benefits from transcatheter arterial chemoembolization (TACE), even for intermediate HCC (Barcelona Clinic Liver Cancer stage B). The aim of this study was to investigate prognostic significance of serum gamma-glutamyl transferase (GGT) in patients with intermediate HCC treated with TACE. Methods A total of 277 patients with intermediate HCC were consecutively treated with TACE and overall survival (OS) was evaluated with the Kaplan-Meier method. Significant difference was estimated with the Log rank method according to GGT value before treatment. Univariate and multivariate analyses were used for the study of significance of prognostic factor. Results The median follow-up period was 18.7 months. The 1-year and 3-year OS rates were 71.6 and 38.5% in patients with normal GGT and 48.8 and 16.9% in patients with high GGT (P = 0.002). High GGT, correlating with higher tumor size, alpha-fetoprotein (AFP), and alanine aminotrasferase, was an independent prognostic factor for OS (P = 0.009). Others included tumor size and ascites. Furthermore, in small HCC and normal AFP subgroup, serum GGT was also correlated with OS (P = 0.013 and 0.041, respectively). The combination of GGT and AFP had a better power to predict the TACE effects. Conclusion GGT level was an important prognostic factor to predict prognosis of patients with intermediate HCC treated with TACE. Eur J Gastroenterol Hepatol 23: 787-793 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.
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