Inflammatory bowel disease and pregnancy: report of two cases treated with infliximab and a review of the literature

Inflammatory bowel disease is relatively frequent in women of childbearing age. Disease management requires greater attention during this clinical condition because of potential risk of maternal-fetal complications. Infliximab has been shown to be safe during pregnancy and lactation, but reports in the literature are scarce. We report two cases of refractory Crohn's disease treated with infliximab with good results, in women. Both patients became pregnant during maintenance regimen and treatment was continued. The literature regarding pregnant patients with inflammatory bowel disease was reviewed. Eur J Gastroenterol Hepatol 22: 1260- 1264 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.