期刊
ANNALS OF HEMATOLOGY
卷 95, 期 1, 页码 35-40出版社
SPRINGER
DOI: 10.1007/s00277-015-2500-2
关键词
Bcl-6; Follicular helper T cell; Germinal center; Interleukin-21; Multicentric Castleman's disease
类别
资金
- Ministry of Health Labour and Welfare, Japan
- Japan Rheumatism Foundation
Both multicentric Castleman's disease (MCD) and immunoglobulin (Ig)G4-related disease (IgG4-RD) are systemic diseases, presenting with hypergammaglobulinemia and elevated serum levels of IgG4. However, with regard to histopathological findings, MCD shows atrophic germinal centers. On the other hand, expanded germinal centers are detected in IgG4-RD. We extracted germinal centers from specimens of each disorder by microdissection and analyzed the expression of mRNAs by real-time polymerase chain reaction to clarify the mechanisms underlying atrophied germinal centers in MCD. This analysis disclosed loss of interleukin (IL)-21 and B cell lymphoma (Bcl)-6 in the germinal centers of MCD. Loss of IL-21 is considered to be involved in the disappearance of Bcl-6 and leads to atrophied germinal centers in MCD.
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