期刊
EUROPEAN JOURNAL OF EPIDEMIOLOGY
卷 29, 期 9, 页码 629-638出版社
SPRINGER
DOI: 10.1007/s10654-014-9940-1
关键词
Telomere length; Adipocytokines; Leptin; Oxidative stress; Inflammation
资金
- Netherlands Organisation for Scientific Research (NWO)
- Erasmus MC
- Centre for Medical Systems Biology (CMSB)
- European Community [HEALTH-F4-2007-201413]
- ENGAGE Consortium [HEALTH-F4-2007-201413]
- Netherlands Consortium for Healthy Ageing [050-060-810]
- Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
- German Federal Ministry of Education and Research (BMBF)
- German National Genome Research Network (NGFN) [01GS0834]
- Munich Center of Health Sciences (MC Health)
- Tiroler Wissenschaftsfonds [UNI-0407/29]
- Genomics of Lipid-associated Disorders-GOLD of the Austrian Genome Research Programme GEN-AU
- European Union [259679]
- Innovation-Oriented Research Program on Genomics [SenterNovem IGE05007]
- Centre for Medical Systems Biology
- Netherlands Genomics Initiative, Netherlands Organization for Scientific Research (NWO)
- Unilever Colworth
- Wellcome Trust
- Dept of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre
- King's College London
- ERC
- National Eye Institute via an NIH/CIDR genotyping project
- Austrian Heart Fund
- Kamillo-Eisner Stiftung
- Salzburger Forschungsgesellschaft
- Oesterreichische Nationalbank (OeNB) [13339]
- Paracelsus Medical University (FFF-PMU) [E-09/09/055-PAU]
- Helsinki University Hospital
- Novo Nordisk
- Diabetes Research Foundation
- Finnish Foundation for Cardiovascular Research
- Biomedicum Helsinki
- Jalmari and Rauha Ahokas Foundation
- Academy of Finland Centre of Excellence in Complex Disease Genetics
- National Institute of Alcohol Abuse and Alcoholism [AA-12502, AA-09203]
- Academy of Finland [44069, 205585, 118555, 141054]
- EU [FP7-KBBE-22270, FP7-HEALTH-F4-2007]
Oxidative stress and inflammation are major contributors to accelerated age-related relative telomere length (RTL) shortening. Both conditions are strongly linked to leptin and adiponectin, the most prominent adipocyte-derived protein hormones. As high leptin levels and low levels of adiponectin have been implicated in inflammation, one expects adiponectin to be positively associated with RTL while leptin should be negatively associated. Within the ENGAGE consortium, we investigated the association of RTL with adiponectin and leptin in seven independent cohorts with a total of 11,448 participants. We performed partial correlation analysis on Z-transformed RTL and LN-transformed leptin/adiponectin, adjusting for age and sex. In extended models we adjusted for body mass index (BMI) and C-reactive protein (CRP). Adiponectin showed a borderline significant association with RTL. This appeared to be determined by a single study and when the outlier study was removed, this association disappeared. The association between RTL and leptin was highly significant (r = -0.05; p = 1.81 x 10(-7)). Additional adjustment for BMI or CRP did not change the results. Sex-stratified analysis revealed no difference between men and women. Our study suggests that high leptin levels are associated with short RTL.
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