期刊
EUROPEAN JOURNAL OF EPIDEMIOLOGY
卷 27, 期 10, 页码 781-790出版社
SPRINGER
DOI: 10.1007/s10654-012-9727-1
关键词
Childhood leukemia; Benzene; PM10; Case-control study; Traffic
资金
- Associazione Sostegno Oncologia Ematologia Pediatrica-ASEOP
- Department of the Environment of Reggio Emilia Municipality
- US National Institute of Health [NIH CA16042]
Benzene, a recognized occupational leukemogen in adults, has been hypothesized to also increase the risk of childhood leukemia. We carried out a population-based case-control study in a northern Italy community involving 83 cases with acute childhood leukemia diagnosed in the years 1998-2009 and 332 matched controls. We assessed residential exposure to benzene and to particulate matter a parts per thousand currency sign10 mu m (PM10) from motorized traffic using geocoded residences and detailed emission and dispersion modeling. Exposure to benzene, and to a lesser extent to PM10, appeared to be independently associated with an excess leukemia risk. When we stratified the study population by age and by leukemia subtype, the relative risk associated with benzene exposure was higher among children aged less than 5 years, and despite small numbers this relation appeared to be considerably stronger for acute myeloid leukemia than for acute lymphoblastic leukemia. Overall, these findings suggest that exposure to low levels of benzene released from motorized traffic may increase the risk of childhood leukemia, and suggest a possible independent effect of PM10, although unmeasured confounding due to other pollutants cannot be ruled out.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据