Hypothalamic obesity: prevalence, associations and longitudinal trends in weight in a specialist adult neuroendocrine clinic

Objective: Obesity is highly prevalent among adults with acquired, structural hypothalamic damage. We aimed to determine hormonal and neuroanatomical variables associated with weight gain and obesity in patients following hypothalamic damage and to evaluate the impact of early instigation of weight loss measures to prevent or limit the severity of obesity in these patients. Design: Retrospective study of 110 adults with hypothalamic tumours attending a specialist neuroendocrine clinic. BMI was calculated at diagnosis and at last follow-up clinic visit. Endocrine data, procedures, treatments and weight loss measures were recorded and all available brain imaging reviewed. Results: At last follow-up, 82.7% of patients were overweight or heavier (BMI >= 25 kg/m(2)), 57.2% were obese (BMI >= 30 kg/m(2)) and 14.5% were morbidly obese (BMI >= 40 kg/m(2)). Multivariate analysis revealed that use of desmopressin (odds ratio (OR) = 3.5; P = 0.026), GH (OR = 2.7; P = 0.031) and thyroxine (OR = 3.0; P = 0.03) was associated with development of new or worsened obesity. Neuroimaging features were not associated with weight gain. Despite proactive treatments offered in clinic in recent years (counselling, dietetic and physical activity advice, and anti-obesity medications), patients have continued to gain weight. Conclusions: Despite increased awareness, hypothalamic obesity is difficult to prevent and to treat. Improved understanding of the underlying pathophysiologies and multicentre collaboration to examine efficacy of novel obesity interventions are warranted. European Journal of Endocrinology 168 501-507