Chemerin is associated with markers of inflammation and components of the metabolic syndrome but does not predict coronary atherosclerosis

Objectives: Chemerin is a recently discovered adipokine that regulates adipocyte differentiation and modulates chemotaxis and activation of dendritic cells and macrophages. Given the convergence of adipocyte and macrophage function, chemerin may provide an interesting link between obesity. inflammation and atherosclerosis in humans. We sought to examine the relationship of i) chemerin and markers of inflammation, ii) chemerin and components of the metabolic syndrome. and iii) chemerin and coronary atherosclerotic plaque burden and morphology. Design: Serum chemerin levels were determined in 303 patients with stable typical or atypical chest Pain Who Underwent dual-source multi-slice CT-angiography to exclude coronary artery stenosis. Atherosclerotic plaques were classified its calcified, mixed. or non-calcified. Results: Chemerin levels were highly correlated with high sensitivity C-reactive protein (r=0.44. P<0.0001). interleukin-6 (r=0.18, P=0.002), tumor necrosis factor-alpha. (r=0.24, P<0.0001). resistin (r=0.28. P<0.0001), and leptin r=0.36. P<0.0001) concentrations. Furthermore, chemerin was associated with components of the metabolic syndrome including body mass index (r=0.23, P=0.0002). triglycerides (r=0.29. P<0.0001), HDL-cholesterol (r=-0.18, P=0.003). and hypertension (P<0.0001). In bivariate analysis. chemerin levels were weakly correlated with coronary plaque burden (r=0.16. P=0.006) and the number of non-calcified plaques (r=0.14. P=0.02). These associations, however, were lost after adjusting for established cardiovascular risk factors (odds ratio. OR 1.17, 95%, confidence interval (Cl) 0.97-1.41. P=0.11 for coronary plaque burden: OR 1.06, 95% Cl 0.96-1.17. P=0.22 for non-calcified plaques). Conclusions: Chemerin is strongly associated with markers of inflammation and components of the metabolic syndrome. However, chemerin does not predict coronary, atherosclerosis.