期刊
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
卷 40, 期 2, 页码 219-224出版社
SPRINGER FRANCE
DOI: 10.1007/s13318-014-0199-4
关键词
Pharmacokinetic; Herb-drug interaction; Sildenafil; Lepidium sativum; Nigella sativa; Trigonella foenum-graecum
资金
- Deanship of Scientific Research, King Saud University, Riyadh, Saudi Arabia [DSR-AR-2-20]
The present study was conducted to investigate the effects of some commonly used herbs namely Nigella sativa, Lepidium sativum and Trigonella foenum-graecum on the pharmacokinetics of sildenafil in beagle dogs. The study design involved four treatments in a non-balanced crossover design. Sildenafil was given one tablet 100 mg orally to each dog and blood samples were obtained. After a suitable washout period, animals were commenced on a specific herb treatment for 1 week. Blood samples were withdrawn at different time intervals and sildenafil was analyzed by HPLC method. Oral administration of Nigella sativa resulted in reduction of AUC(0-a), C (max) and t (1/2) as compared to the control. Treatment of Lepidium sativum resulted in a significant reduction in the C (max) and AUC. There were no significant differences between the rests of the pharmacokinetic parameters relative to those of the control. For Trigonella foenum-graecum, the effects were similar to those obtained in case of Lepidium sativum. It was concluded that concurrent use of investigated herbs alters the pharmacokinetics of sildenafil. Co-administration of investigated herbs should be cautious since their concomitant use might result in decrease in sildenafil bioavailability.
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