期刊
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
卷 67, 期 9, 页码 885-887出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00228-011-1009-4
关键词
HLA-B*1502; Carbamazepine; Stevens-Johnson syndrome; Toxic epidermal necrolysis; Mainland Chinese
资金
- National Natural Science Foundation of China [30973597]
- Key Funds for Major State Basic Research Program of Suzhou [SYS201001]
- Chinese National High Technology Research and Development Program 863 [2008AA02Z436]
The purpose of this study is to examine the association of HLA-B*1502 allele with CBZ-induced SJS/TEN in the mainland Han Chinese population. HLA-B*1502 genotyping with sequence-specific primer polymerase chain reaction (PCR-SSP) and PCR-sequencing based typing (PCR-SBT) was performed on 17 CBZ-induced SJS/TEN patients, 21 CBZ-tolerant controls, and 185 healthy controls recruited during 2008-2010. HLA-B*1502 allele was present in 94.1% (16/17) of CBZ-SJS/TEN patients, 9.5% (2/21) of CBZ-tolerant patients, and 9.2% (17/185) of healthy controls. The risk of CBZ-induced SJS/TEN was significantly higher (P < 0.01) in the patients with HLA-B*1502. One CBZ-induced SJS patient tested negative for HLA-B*1502, and the test result showed HLA-B*3503/B*4601. We found a strong association between HLA-B*1502 and CBZ-induced SJS/TEN in the Han Chinese population from central and northern China. Combined with previous studies of the southern Han Chinese subpopulation, our results suggest that HLA-B*1502 is strongly associated with CBZ-induced SJS/TEN in the whole Han Chinese population.
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