期刊
EUROPEAN JOURNAL OF CLINICAL NUTRITION
卷 73, 期 5, 页码 703-713出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41430-018-0272-1
关键词
-
资金
- NCI [R37 CA54281, U01 CA164973, P30 CA71789]
- German Research Foundation (PROMOS)
- Susanne Marie Sophie Haufen Foundation
Background/Objectives This study examined the long-term relation of lipid-soluble micronutrients with diet quality as assessed by four a priori-defined dietary patterns. Subjects/Methods In a prospective design, nutritional biomarkers (carotenoids, tocopherols, retinol, and coenzyme Q10) were measured using a validated HPLC-based assay. General linear models were applied to obtain covariate-adjusted means of biomarkers for tertiles of four a priori diet quality indices: Healthy Eating Index (HEI) 2010, Alternative HEI (AHEI) 2010, Alternate Mediterranean Diet Score (aMED), and Dietary Approaches to Stop Hypertension (DASH). For a subcohort of 8367 participants within the Multiethnic Cohort (MEC), diet was assessed by a validated quantitative food frequency questionnaire in 1993-96 and serum was collected in 2001-06. Results Participants with the highest diet-quality scores had significantly higher serum concentrations of all carotenoids, total tocopherols, and alpha-tocopherol, whereas gamma-tocopherol was inversely associated with diet quality. Adjusted means for the lowest vs. highest tertile of HEI 2010 were 1.2 vs. 1.5 mg/L for total carotenoids, 11.4 vs. 12.3 mg/L for total tocopherols, and 1.9 vs. 1.6 mg/L for gamma-tocopherol (p(trend) < 0.0001). The associations for the other dietary indices were similar; no indication for sex and ethnic differences was detected. Vegetable and fruit components were major predictors of most circulating micronutrients, but most other components were also associated. Conclusions Higher diet-quality scores measured by four a priori diet quality indices were significantly associated higher serum concentrations of carotenoids and alpha-tocopherol, whereas gamma-tocopherol was inversely associated with diet quality.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据