期刊
EUROPEAN JOURNAL OF CLINICAL NUTRITION
卷 68, 期 5, 页码 632-634出版社
SPRINGERNATURE
DOI: 10.1038/ejcn.2013.278
关键词
women; Metabolism; vitamin D; pharmacokinetics
资金
- NIH/NCRR CTSA [UL1 RR024150]
- Mayo Clinic Pharmacy Services Discretionary Fund
This study compared serum cholecalciferol and 25-hydroxyvitamin D (25(OH)D) concentrations over four weeks in healthy, nob-pregnant, non-lactating females aged 18-40 years, Who were randomized to oral cholecalciferol 5000 international units (IU) daily for 28 days or a single dose of 150 000IU. The study was conducted in Rochester, MN in March and April of 2010. We found no difference in mean 25(OH)D between treatment groups on study day 0 or day 28 (P=0.14 and 0.28, respectively). The daily group had 11 more days of detectable serum cholecalciferol than the single-dose group (P<0.001). There was no difference observed in cholecalciferol area under the curve (AUC(28)) between groups (P=0.49). However, the single-dose group had a significantly greater mean 25(OH)D AUC(28) compared with the daily group (P<0.001).
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