期刊
EUROPEAN JOURNAL OF CLINICAL NUTRITION
卷 64, 期 7, 页码 669-677出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ejcn.2010.65
关键词
probiotics; clinical trial; infections; functional foods
资金
- The Dannon Company, Inc
Background: To evaluate whether a fermented dairy drink containing the probiotic strain Lactobacillus casei DN-114 001 could reduce the incidence of common infectious diseases (CIDs) and the change of behavior because of illness in children. Subjects/Methods: We conducted a double-blinded, randomized, placebo-controlled allocation concealment clinical trial in the Washington, DC metropolitan area. Participants were 638 children 3-6 years old in daycare/schools. The intervention was a fermented dairy drink containing a specific probiotic strain or matching placebo with no live cultures for 90 consecutive days. Two primary outcomes were assessed: incidence of CIDs and change of behavior because of illness (both assessed by parental report). Results: The rate of change of behavior because of illness was similar among active and control groups. However, the incidence rate for CIDs in the active group (0.0782) is 19% lower than that of the control group (0.0986) (incidence rate ratio = 0.81, 95% CI: 0.65, 099) P=0.046. Conclusions: Daily intake of a fermented dairy drink containing the probiotic strain L. casei DN-114 001 showed some promise in reducing overall incidence of illness, but was primarily driven by gastrointestinal infections and there were no differences in change of behavior. European Journal of Clinical Nutrition (2010) 64, 669-677; doi:10.1038/ejcn.2010.65; published online 19 May 2010
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据