期刊
EUROPEAN JOURNAL OF CLINICAL NUTRITION
卷 64, 期 4, 页码 432-435出版社
SPRINGERNATURE
DOI: 10.1038/ejcn.2010.6
关键词
bioavailability; biokinetics; humans; quercetin; hesperetin; naringenin
资金
- Research Centre for Environmental Health (ISMF)
- Danish Technical Research Council (FELFO)
- Hede Nielsen Family Foundation
The bioavailability and urinary excretion of three dietary flavonoids, quercetin, hesperetin and naringenin, were investigated. Ten healthy men were asked to consume a 'juice mix' containing equal amounts of the three flavonoids, and their urine and plasma samples were collected. The resulting mean plasma area under the curve (AUC)(0-48h) and C-max values for quercetin and hesperetin were similar, whereas the AUC(0-48h) of naringenin and, thus, the relative bioavailability were higher after consumption of the same dose. The study consolidates a significantly lower urinary excretion of quercetin (1.5 +/- 1%) compared with hesperetin (14.2 +/- 9.1%) and naringenin (22.6 +/- 11.5%) and shows that this is not due to a lower bioavailability of quercetin, but rather reflects different clearance mechanisms. European Journal of Clinical Nutrition (2010) 64, 432-435; doi: 10.1038/ejcn.2010.6; published online 3 February 2010
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