期刊
EUROPEAN JOURNAL OF CLINICAL NUTRITION
卷 63, 期 5, 页码 640-645出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ejcn.2008.17
关键词
arteries; atherosclerosis; breast feeding; risk factors; ultrasound
资金
- Academy of Finland [77841, 210283]
- Social Insurance Institution of Finland
- Turku University Foundation
- Juho Vainio Foundation
- Finnish Foundation of Cardiovascular Research
- Lydia Maria Julin Foundation
- Research Foundation of Instrumentarium
- Research Foundation of Orion Corporation
- Maud Kuistila Foundation
- Emil Aaltonen Foundation
- Finnish Medical Foundation
- Finnish Cultural Foundation
- Academy of Finland (AKA) [210283] Funding Source: Academy of Finland (AKA)
Background/Objectives: Breast feeding in infancy may be associated with reduced cardiovascular morbidity in adulthood. We examined the association between breast feeding in infancy and arterial function and structure in adulthood in a population-based cohort of Finnish adults. Subjects/Methods: Noninvasive ultrasound was used to measure brachial artery flow-mediated dilatation (FMD), carotid artery intima-media thickness (IMT) and carotid artery compliance (CAC) in 1667 young adults participating in the Cardiovascular Risk in Young Finns Study with data on early nutrition. Results: Maximal FMD was higher in breast-fed men compared to formula-fed men (7.2 +/- 4.0 vs 5.9 +/- 3.4%, P = 0.029) while no differences were seen between breast-fed and formula-fed women (8.9 +/- 4.5 vs 8.8 +/- 5.0%, P = 0.84). In men, the multivariable correlates of FMD included the group variable for breast feeding (P = 0.014), birth weight (P = 0.043), waist circumference (P < 0.001) and baseline brachial artery diameter (P < 0.001). In women, the multivariable correlates of FMD were birth weight (P = 0.02), waist circumference (P < 0.001) and brachial artery baseline diameter (P < 0.001). Breast feeding was not significantly associated with IMT or CAC in multivariable models. Conclusions: Adult men who have been breast fed have better brachial endothelial function compared to men who have been formula fed. European Journal of Clinical Nutrition (2009) 63, 640-645; doi:10.1038/ejcn.2008.17; published online 20 February 2008
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