期刊
JOURNAL OF SULFUR CHEMISTRY
卷 37, 期 2, 页码 148-161出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/17415993.2015.1114117
关键词
thiazolidin-5-one; phenacyl bromide; thioacetoacetanilide; thiophene; diazonium chloride; Phenyl isothiocyanate; thiadiazole
The behavior of thioacetoacetanilide (1) and/or alpha-arylhydrazono-thioacetoacetanilides 4 toward many different alpha-halocarbonyl compounds was demonstrated. Thus, reactions of 1 with alpha-bromoketones (bromoacetone and phenacyl bromide) and hydrazonoyl bromides afforded the corresponding thiazole, thiophene and 1,3,4-thiadiazole derivatives, respectively. The synthesis and reactivity of thiazolidin-5-one 2 toward aromatic diazonium chlorides and aromatic aldehydes were described. Most of the synthesized compounds were screened for their antibacterial and antifungal activities and showed accepted antimicrobial activities with respect to the control drugs.
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