期刊
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
卷 43, 期 8, 页码 886-893出版社
WILEY
DOI: 10.1111/eci.12135
关键词
Apoptosis; autophagy; cristae; ER-mitochondria tethering; fusion fission; mitochondria
资金
- Telethon Italy
- AIRC Italy
- Swiss National Foundation
- ERC
- FIRB Italy
- MOH GR Italy
- Fondazione Cariparo
Background Mitochondria are dynamic organelles that participate in energy conversion, metabolism, signaling and apoptosis. To fulfill their multiple tasks, mitochondria come in varied morphologies and ultrastructures resulting from the equilibrium between fusion and fission, Furthermore, they are in close contact with the endoplasmic reticulum generating an essential interface in cell physiology and death. Materials and Methods In this review we will discuss the impact of our findings on the molecular mechanisms of mitochondrial morphology and tethering to the endoplasmic reticulum on cell death. Results and Conclusions The work reviewed here supports a key role for mitochondrial dynamics in cell life and death and in disease.
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