期刊
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
卷 43, 期 4, 页码 405-412出版社
WILEY
DOI: 10.1111/eci.12055
关键词
Arterial calcification; ATP; purinergic system
资金
- Kidney Research UK Clinical Research Training Fellowship
- Kidney Research UK [TF20/2011] Funding Source: researchfish
Background Arterial calcification (AC) is a major health problem associated with extreme morbidity and a shortened survival. It is currently without any effective treatment. ATP and the purinergic system in general are now emerging as being important in the pathogenesis of AC and potentially provide a new focus for novel therapies. Methods This review systematically analyses and discusses the current literature examining the relevance of the purinergic system to AC. Particular emphasis is given to the enzymes associated with ATP metabolism and their role in maintaining a balance between promotion and inhibition of arterial mineralization. Points of controversy are highlighted, and areas for future research are suggested. Conclusion The potential roles of ATP and the purinergic system in AC are beginning to be elucidated. While further work is necessary, current knowledge suggests that several components of the purinergic system could be targeted to develop new treatments for AC.
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