期刊
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
卷 41, 期 1, 页码 52-58出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1365-2362.2010.02376.x
关键词
Electronic nose; mechanical; complications; ventilation; ventilator associated pneumonia
资金
- Cheltenham Intensive Care Trust
- National Institute for Health Research [CSA/03/07/017] Funding Source: researchfish
P>Background Electronic nose (E-nose) technology has been successfully used to diagnose a number of microbial infections. We have investigated the potential use of an E-nose for the diagnosis of ventilator-associated pneumonia (VAP) by detecting micro-organisms in bronchoalveolar lavage (BAL) fluid in a prospective comparative study of E-nose analysis and microbiology. Materials and methods BAL samples were collected using a blind technique from 44 patients following a minimum of 72 h mechanical ventilation. Control samples were collected from six patients mechanically ventilated on the intensive care unit (ICU) immediately following elective surgery. Quantitative microbiological culture and E-nose headspace analysis of the BAL samples were undertaken. Multivariate analysis was applied to correlate E-nose response with microbiological growth. Results E-nose fingerprints correctly classified 77% of the BAL samples, with and without microbiological growth from patients not on antibiotics. Inclusion of patients on antibiotics resulted in 68% correct classification. Seventy per cent of isolates, cultured in the laboratory from the clinical samples, were accurately discriminated into four clinically significant groups. Conclusions E-nose technology can accurately discriminate between different microbial species in BAL samples from ventilated patients on ICU at risk of developing VAP with accuracy comparable with accepted microbiological techniques.
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