期刊
EUROPEAN JOURNAL OF CELL BIOLOGY
卷 93, 期 1-2, 页码 61-70出版社
ELSEVIER GMBH
DOI: 10.1016/j.ejcb.2013.11.007
关键词
Oncogene; Transcription factor; Translational regulation; DNA repair; Proliferation; Survival; Migration/invasion; Chemoresistance; Angiogenesis; Genomic instability
类别
资金
- Melanoma Research Network of the Deutsche Krebshilfe e.V. (German Cancer Aid)
Y-box binding protein 1 (YB-1) is a multifunctional protein involved in various cellular processes including both transcriptional and translational regulation of target gene expression. Significantly increased YB-1 levels have been reported in a number of human malignancies and shown to be associated with poor prognosis and disease recurrence. Indeed, YB-1 can act as a versatile oncoprotein playing an important role in tumour cell proliferation and progression. Consequently, YB-1 not only proves to be a good prognostic tumour marker, but also may be a promising emerging molecular target for the development of new therapeutical strategies. In this review, we discuss both the role of YB-1 in cancer and specifically in malignant melanoma as well as possible translations into the clinics derived thereof. (C) 2014 Elsevier GmbH. All rights reserved.
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