期刊
EUROPEAN JOURNAL OF CELL BIOLOGY
卷 93, 期 10-12, 页码 466-477出版社
ELSEVIER GMBH
DOI: 10.1016/j.ejcb.2014.06.003
关键词
Dock180; Dock1; Dock2; Dock3; Dock4; Dock5; Dock6; Dock7; Dock8; Dock9; Dock10; Dock11; Zizimin; DHR2; Rac1; Cdc42; Adhesion; Migration; Cancer; Exchange factor; Rho GTPase; Osteoclast; Amoeboid; GPCR; Integrin; Synapse
类别
资金
- Institut National du Cancer [INCa-4361]
- Agence Nationale de la Recherche [ANR-2011-BLAN-006]
Dock family proteins are evolutionary conserved exchange factors for the Rho GTPases Rac and Cdc42. There are 11 Dock proteins in mammals, named Dock1 (or Dock180) to Dock11 that play different cellular functions. In particular, Dock proteins regulate actin cytoskeleton, cell adhesion and migration. Not surprisingly, members of the Dock family have been involved in various pathologies, including cancer and defects in the central nervous and immune systems. This review proposes an update of the recent findings regarding the function of Dock proteins, focusing on their role in the control of cell migration and invasion and the consequences in human diseases. (C) 2014 Elsevier GmbH. All rights reserved.
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