期刊
EUROPEAN JOURNAL OF CELL BIOLOGY
卷 93, 期 1-2, 页码 36-41出版社
ELSEVIER GMBH
DOI: 10.1016/j.ejcb.2013.11.005
关键词
Melanoma; Reactive oxygen species; Transsulfuration pathway; Carcinogenesis; Senescence; Melanocytes
类别
资金
- German Cancer Aid (Melanoma Research Network)
- German Research Foundation [TRR-17]
- interdisciplinary center for clinical research (IZKF) Wurzburg
- Hiege Foundation against skin cancer
Melanoma is a severe type of skin cancer with a high metastasis potential and poor survival rates once metastasized. The causes of melanoma formation are multifactorial and not fully understood. Several signaling cascades such as the RAS/RAF/ERK1/2 pathway, the PI3K/AKT pathway, RAC1 and NF-kappa B are involved in melanoma initiation and progression. Reactive oxygen species (ROS) are induced by these signal transduction cascades, and they play a fundamental role in melanomagenic processes. Cells derived from the melanocytic lineage are particularly sensitive to an increase in ROS, and thus, melanoma cells rely on efficient antioxidant measures. This review summarizes the causes and consequences of ROS generation in melanocytes and melanoma and discusses the potential of pro-oxidant therapy in melanoma treatment. (C) 2013 Elsevier GmbH. All rights reserved.
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