期刊
EUROPEAN JOURNAL OF CELL BIOLOGY
卷 91, 期 6-7, 页码 524-532出版社
ELSEVIER GMBH
DOI: 10.1016/j.ejcb.2011.09.005
关键词
Cytokines; Receptors; Signal transduction; JAK; STAT
类别
资金
- Deutsche Forschungsgemeinschaft [SFB 542]
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway directly links ligand-binding to a membrane-bound receptor with the activation of a transcription factor. This signalling module enables the cell to rapidly initiate a transcriptional response to external stimulation. The main components of this evolutionary conserved module are cytokines that specifically bind to cytokine receptors leading to the activation of receptor-associated Janus tyrosine kinases (JAKs). The receptor-bound JAKs activate STAT transcription factors through phosphorylation of a single tyrosine residue. Activated STAT dimers translocate into the nucleus to induce target gene expression. In this article we will review current opinions on the molecular mechanism and on intracellular dynamics of JAK/STAT signalling with a special focus on the cytokine receptor glycoprotein 130 (gp130) and STAT3. In particular we will concentrate on non-canonical aspects of Jak/STAT signalling including preassembled receptor complexes, preformed STAT dimers, STAT trafficking and non-canonical functions of STATs. (C) 2011 Elsevier GmbH. All rights reserved.
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