期刊
EUROPEAN JOURNAL OF CELL BIOLOGY
卷 91, 期 4, 页码 287-293出版社
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.ejcb.2011.05.004
关键词
TGF-beta; BMP receptor; Interactome
类别
资金
- Deutsche Forschungsgemeinschaft [SFB 449]
An immense number of cellular processes are initiated by cell surface serine/threonine kinase receptors belonging to the TGF-beta/BMP family. Subsequent downstream signalling cascades, as well as their crosstalk results in enormous specificity in terms of phenotypic outcome, e.g. proliferation, differentiation, migration or apoptosis. Such signalling diversity is achieved by the ability of receptors to interact with distinct proteins in a spatio-temporal manner. Following the cloning of the TGF-beta/BMP receptors a variety of different technologies were applied to identify such interacting proteins. Here we present a comprehensive survey of known interactome analyses, including our own data, on these receptors and discuss advantages and disadvantages of the applied technologies. (C) 2011 Elsevier GmbH. All rights reserved.
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