期刊
EUROPEAN JOURNAL OF CELL BIOLOGY
卷 90, 期 9, 页码 779-785出版社
ELSEVIER GMBH
DOI: 10.1016/j.ejcb.2011.04.007
关键词
Ypt7; CORVET; Mon1; Ccz1; HOPS; Endosome; Vacuole; Vps21
类别
资金
- Sonderforschungsbereich [431, 351, 688]
Membrane fusion at late endosomes and vacuoles depends on a conserved machinery, which includes Rab GTPases, their binding to tethering complexes and SNAREs. Fusion is initiated by the interaction of Rabs with tethering complexes. At the endosorne, the CORVET complex interacts with the Rab5 GTPase Vps21, whereas the homologous HOPS complex binds the Rab7-like Ypt7 at the late endosome and vacuole. Activation of Ypt7 requires the recruitment of the Mon1-Ccz1 complex to the late endosome, which occurs via the CORVET complex. The interaction of Rab and the tethering complex is followed by the assembly of SNAREs, which leads to bilayer mixing. In this review, we will summarize our current knowledge on the mechanisms and regulation of endosome and vacuole membrane dynamics, and their role in organelle physiology. (C) 2011 Elsevier GmbH. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据