期刊
EUROPEAN JOURNAL OF CELL BIOLOGY
卷 87, 期 8-9, 页码 669-676出版社
ELSEVIER GMBH
DOI: 10.1016/j.ejcb.2008.01.002
关键词
invasion; contractile forces; 3-D traction microscopy; metastasis; signal transduction
类别
资金
- Czech Republic [301/06/1147]
- Ministry of Education of the Czech Republic [LC06061]
- Deutsche Krebshilfe [107384]
- DFG [FA336/2-1]
- NIH [HL65960]
Cancer is a deadly disease primarily because of the ability of tumor cells to spread from the primary tumor, to invade into the connective tissue. and to form metastases at distant sites. In contrast to cell migration on a planar Surface,where large cell tractions and contractile forces are not essential, tractions and forces Lire thought to be crucial for overcoming the resistance and steric hindrance of a dense three-dimensional connective tissue matrix. In this review, we describe recently developed biophysical tools, including 2-D and 3-D traction microscopy to measure contractile forces of cells. We discuss evidence indicating that tumor cell invasiveness is associated with increased contractile force generation. (C) 2008 Elsevier GmbH. All rights reserved.
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