期刊
EUROPEAN JOURNAL OF CELL BIOLOGY
卷 87, 期 8-9, 页码 491-506出版社
ELSEVIER GMBH
DOI: 10.1016/j.ejcb.2008.02.012
关键词
cell adhesion; focal adhesion dynamics; podosome dynamics; cell contractility
类别
资金
- Ligue Nationale Contre le Cancer
- Association de Recherche pour le Cancer
- GEFLUC
- ANR
- Region Rhone-Alpes
- Ministre de l'Education Nationale
- de la Recherche et de la Technologie
- Ministere de l'Education Nationale
Cell-matrix adhesions are essential for cell migration, tissue organization and differentiation, therefore playing central roles in embryonic development, remodeling and homeostasis Of tissue,, and organs. Matrix adhesion-dependent signals cooperate with other pathways to regulate biological functions such as cell survival, Cell proliferation. Wound healing, and tumorigenesis. Cell migration and invasion are integrated processes requiring the continuous. coordinated assembly and disassembly of integrin-mediated adhesions. All understanding of how integrins regulate cell migration and invasiveness through the dynamic regulation of adhesions is fundamental to both physiological and pathological Situations. A variety of cell-matrix adhesions has been identified, namely, focal complexes, focal adhesions, fibrillar adhesions, podosomes, and invadopodia (podosome-type adhesions). These adhesion sites contain integrin Clusters able to develop specialized Structures, which are different in their architecture and dynamics although they share almost the same proteins. Here we compare recent advances and developments in the elucidation of the organization and dynamics of focal adhesions and podosome-type adhesions, in order to understand how such subcellular sites - though closely related in their composition - can be Structurally and functionally different. The underlying question is how their respective physiological or pathological roles are related to their distinct organization. (C) 2008 Elsevier GmbH. All rights reserved.
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