期刊
EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION
卷 18, 期 2, 页码 312-319出版社
SAGE PUBLICATIONS LTD
DOI: 10.1097/HJR.0b013e32833c1aa3
关键词
Body mass index; cardiovascular disease; type-2 diabetes; waist circumference; waist-to-hip ratio
资金
- Servier
- National Health and Medical Research Council of Australia
- Institut Servier-France
- Assistance Publique-Hopitaux de Paris, France
- Heart Foundation of Australia
- UK MRC
- Chief Scientist Office at the Scottish Government Health Directorates
- Medical Research Council [MC_U130059821] Funding Source: researchfish
- MRC [MC_U130059821] Funding Source: UKRI
Aims: The aim of this study was to compare the strength of associations and discrimination capability of body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR) with cardiovascular disease risk in individuals with type-2 diabetes. Methods and results: Eleven thousand, one hundred and forty men and women were followed for a mean of 4.8 years. The Cox proportional hazard models were used to compute the hazard ratios and 95% confidence intervals (95% CI) for one standard deviation (SD) increase in baseline BMI (SD: 5kg/m(2)), WC (SD: 13cm) and WHR (SD: 0.08) with cardiovascular disease risk. After adjustment, hazard ratio (95% CI) for WC were 1.10 (1.03-1.18) for cardiovascular events, 1.13 (1.03-1.24) for coronary events, and 1.08 (0.98-1.19) for cardiovascular deaths. Estimates for WHR were 1.12 (1.05-1.19), 1.17 (1.08-1.28) and 1.19 (1.09-1.31). BMI was not related to any of these outcomes. Although the receiver operating characteristic curve could not differentiate between anthropometric variables (P values >= 0.24), the relative integrated discrimination improvement statistic showed an enhancement in the discrimination capabilities of models using WHR for cardiovascular outcomes, except for cerebrovascular events. Conclusion: Strengths of associations and discrimination statistics suggested that WHR was the best predictor of cardiovascular events and mortality in patients with type-2 diabetes and BMI the worst.
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