期刊
EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION
卷 17, 期 2, 页码 168-174出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/HJR.0b013e3283319094
关键词
blood pressure; body mass index; cholesterol; exposure; glucose; intima-media thickness; vascular risk factor
资金
- Dutch Diabetes Research Foundation [2003.01.004]
Background Carotid artery intima-media thickness (IMT) is a measure of atherosclerosis. Levels of vascular risk factors that are associated with increased IMT change over time. This study aimed to examine the time course of vascular risk factors in older persons with 'high' versus 'low' IMT over a 10-year period. Design The Hoorn Study is a population-based cohort study on glucose metabolism and vascular disease initiated in 1989. Methods Carotid IMT was assessed in 2000-2001 (n=581) and in 2005-2007 (n=261). The time course of vascular risk factors from 1989 to 2000-2001 of the group with the highest tertile of IMT in 2000-2001 was compared with the group with the lowest tertile of IMT with linear mixed models, adjusted for age, sex, and medication use. A similar analysis was performed for change in IMT between the 2000-2001 and 2005-2007 examinations. Results Persons in the highest tertile of IMT at follow-up (2000-2001) had a higher waist circumference, BMI, systolic blood pressure, and higher total cholesterol, low-density lipoprotein cholesterol, triglycerides, fasting glucose and glycated haemoglobin levels at baseline (1989) than persons in the lowest tertile. Both groups showed a similar increase in weight, blood pressure and glucose levels over time, but persons in the highest tertile of IMT showed a greater decrease in lipid levels. None of the risk factors were associated with change in IMT over 5 years. Conclusion Persons with increased carotid IMT had an unfavourable risk factor profile throughout the preceding decade. This provides a window of opportunity for early prevention of atherosclerosis. Eur J Cardiovasc Prev Rehabil 17: 168-174 (C) 2010 The European Society of Cardiology
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据