期刊
EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION
卷 15, 期 2, 页码 145-148出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/HJR.0b013e3282efd4e0
关键词
calcium; exercise; myocardium; sarcoplasmic reticulum Ca2+ ATPase
资金
- British Heart Foundation Funding Source: Medline
- NHLBI NIH HHS [HL078797-01A1] Funding Source: Medline
Objective Reduced activity of the sarcoplasmic reticulum Ca2+ ATPase-2a (SERCA-2a) contributes to myocardial dysfunction. Exercise training improves myocardial Ca2+-handling, but SERCA-2a function is uncertain. We assessed SERCA-2a activity after exercise training. Methods SERCA-2a function was assessed by sarcoplasmic reticulum Ca2+ uptake in cardiornyocytes with other Ca2+ uptake mechanisms blocked, in mice after aerobic interval training versus sedentary controls. Results We established protocols to assess SERCA-2a function, and show that aerobic interval training increases the maximal rate of Ca2+ uptake by 30%. This is at least partly explained by reduced phospholamban-to-SERCA-2a ratio. Conclusion Aerobic interval training improves myocardial SERCA-2a performance, explaining at least partly why myocardial Ca2+-handling improves after exercise training.
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