期刊
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
卷 46, 期 5, 页码 779-788出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/ejcts/ezu228
关键词
Ex vivo lung perfusion; Lung transplantation; State-of-the-art review
资金
- United Kingdom Cystic Fibrosis Trust
- Cystic Fibrosis Trust [PJ556] Funding Source: researchfish
- National Institute for Health Research [10/82/01] Funding Source: researchfish
Ex vivo lung perfusion (EVLP) has emerged as a new technique for assessing and potentially reconditioning human donor lungs previously unacceptable for clinical transplantation with the potential to dramatically push the limits of organ acceptability. With the recent introduction of portable EVLP, a new era in lung preservation may be upon us with the opportunity to also limit organ ischaemic times and potentially improve the outcome of donor lungs already deemed acceptable for transplantation. It took over half a century for the technique to evolve from basic theory to semi-automated circuits fit for clinical use that are now rapidly being adopted in transplant centres across the globe. With this field in constant evolution and many unanswered questions remaining, our review serves as an update on the state of the art of EVLP in clinical lung transplantation.
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