期刊
ACS NANO
卷 9, 期 3, 页码 2904-2916出版社
AMER CHEMICAL SOC
DOI: 10.1021/nn506949t
关键词
magnetic nanoparticles; photosensitizer; liposomes; magnetic hyperthermia; photodynamic therapy; cancer combined therapy
类别
资金
- European project Magnifyco [NMP4-SL-2009-228622]
- European Commission under a Marie Curie Intra-European Project [FP7-PEOPLE-20131-IEF-62647]
The ongoing nanotech revolution has the potential to transform diagnostic and therapeutic methods. Stimuli-triggered nanotherapies based on remotely activated agents have become attractive alternatives to conventional chemotherapy. Herein, we designed an optimized smart nanoplatform based on dually loaded hybrid liposomes to achieve enhanced tumor therapy. The aqueous core was highly loaded with iron oxide nanoparticles, while the lipid bilayer was supplied with a photosensitizer payload. The double cargo translated into double functionality: generation of singlet oxygen under laser excitation and heat production under alternating magnetic field stimulation, coupling photodynamic therapy (PDT) to magnetic hyperthermia (MHT). These liposomes address both therapeutic agents within tumor cells, and the combiiied`PDT/MHT therapy resulted in complete cancer cell death in vitro while total solid-tumor ablation was achieved in an in vivo rodent model.
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