期刊
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
卷 34, 期 1, 页码 196-199出版社
OXFORD UNIV PRESS INC
DOI: 10.1016/j.ejcts.2008.03.056
关键词
hepatocellular carcinoma; pulmonary metastasis; extrahepatic metastasis; surgery; metastasectomy
Background: Although favourable prognosis following aggressive treatment of extrahepatic metastases from hepatocellular carcinoma (HCC) has been reported, surgical outcomes for pulmonary metastases are unclear. Methods and materials: Sixty-one patients (2.6%) of 2297 registered with the Metastatic Lung Tumor Study Group of Japan between 1990 and 2006, who underwent surgery for pulmonary metastases from HCC, were retrospectively reviewed from the registry. Results: The overall 5-year survival rate was 32.2%. The prognosis was significantly better for <= 2 lesions than for >= 3 lesions (p = 0.046), for <= 3 lesions than for >= 4 lesions (p = 0.0070), and for <= 4 Lesions than for >= 5 lesions (p = 0.029). No other factors that influence outcomes were identified. A stepwise regression analysis showed three or less pulmonary metastases to be an independent factor for better prognosis (p = 0.048). Conclusion: With careful patient selection, comparatively good outcomes can be expected following surgical resection of pulmonary HCC metastases. Among them, patients with multiple metastases, if number of metastases is small such as four or less, can be expected to survive tong after surgery. (C) 2008 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.
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