期刊
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
卷 34, 期 3, 页码 687-689出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejcts.2008.05.029
关键词
Heparin-induced thrombocytopenia; Cardiopulmonary bypass; Unfractionated heparin; Tirofiban; rFVIIa
Heparin-induced thrombocytopenia was diagnosed in a 50-year-old man on day 5 after cardiac surgery (aorto-coronary bypass and mitral valve replacement). He required redo (para-prosthesis teak) on day 13. The cardiopulmonary bypass (CPB) was performed with unfractionated heparin (UFH) and the platelet glycoprotein (GP) IIb/IIIa inhibitor tirofiban. Post-protamine bleeding likely due to documented persistent platelet blockade by tirofiban was successfully treated with one dose of recombinant activated factor VII (rFVIIa, 60 mu g/kg). No thrombotic complications were detected. The management of CPB with UHF and tirofiban is a convenient option and rFVIIa seems appropriate to handle bleeding issues. (c) 2008 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.
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