期刊
EUROPEAN JOURNAL OF CANCER PREVENTION
卷 17, 期 6, 页码 545-554出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/CEJ.0b013e3282f75ea1
关键词
cervical neoplasia; highly active antiretroviral therapy; human immunodeficiency virus; human papillomavirus
类别
资金
- Department of Reproductive Health and Research
- World Health Organization, Geneva
The objective of this study was to review the literature on the epidemiological association between human papillomavirus (HPV), HIV, and cervical neoplasia, and the impact of highly active antiretroviral therapy (HAART) on this association. MEDLINE was searched using the terms 'human papillomavirus, 'HPV, 'HIV', 'cervix, 'neoplasm', and 'antiretroviral' to identify articles published before December 2006. HIV-infection was strongly associated with a higher prevalence, incidence, and persistence of HPV infection and correlated with prevalence, incidence, persistence, and progression of squamous intraepithelial lesions. The association between HIV and invasive cervical carcinoma has been more difficult to establish, but is now fully recognized. HAART seems to have little, if any, beneficial effect on the natural history of intraepithelial lesions in HIV-positive women. Despite this fact, HAART, does increase the life expectancy of HIV-positive women. Therefore, it remains important to closely monitor HPV-related disease in women with HIV who are receiving HAART, particularly in regions of the world where cervical screening is not available routinely. European Journal of Cancer Prevention 17:545-554 (C) 2008 Wolters Kluwer Health | Lippincott Williams & Wilkins.
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