期刊
EUROPEAN JOURNAL OF CANCER
卷 50, 期 8, 页码 1498-1509出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2014.02.009
关键词
Gastric cancer; Meta-analysis; Incidence; Mortality
类别
Background and aims: Quantification of the association between consumption of fruit and vegetables and risk of gastric cancer (GC) is controversial. We aimed to conduct a meta-analysis of cohort studies to evaluate the associations. Methods: Eligible studies published up to 31st August 2013 were retrieved via both computer searches of PubMed and EMBASE and a manual review of references. Random-effects models were used to calculate summary relative risk (SRR). Heterogeneity among studies was assessed using Cochran's Q and I-2 statistics. Results: A total of 17 articles (24 studies), were included in this meta-analysis. There were >2.4 million individuals (6632 GC events) with a median follow-up of 10 years. Based on the high versus low analysis, consumption of fruit, but not vegetables, may reduce risk of gastric cancer (fruit: SRR = 0.90, 95% confidence interval (CI): 0.83-0.98, P-heterogeneity = 0.450; vegetable: SRR = 0.96, 95% CI: 0.88-1.06, P-heterogeneity = 0.150). Meta regression analysis suggested that outcome (incidence versus mortality) and study quality (high versus low) contributed significantly to heterogeneity. The same results were also shown in the linear dose-response analysis (per 100-g/day) (fruit: SRR = 0.95, 95% CI: 0.91-0.99; vegetable: SRR = 0.96, 95% CI: 0.91-1.01). Significant inverse associations emerged in non-linear models for consumption of fruit (Pnon-linearity = 0.04), but not for consumption of vegetables (Pnon-linearity = 0.551). Conclusions: Findings from this meta-analysis indicate a significant protective effect for the consumption of fruit on GC risk, but not for the consumption of vegetables. (C) 2014 Elsevier Ltd. All rights reserved.
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