期刊
EUROPEAN JOURNAL OF CANCER
卷 48, 期 13, 页码 1957-1968出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2012.01.038
关键词
Lung cancer; Familial aggregation
类别
资金
- Canadian Cancer Society (CCSRI) [020214]
- Cancer Care Ontario Research Chair Award
- Bi-national Israel US Science Foundation (BSF) [2003159]
- Baden-Wurttemberg Ministry of Science Research and Arts
- Steps for Breath and the Labrecque Foundation
- Society of Memorial Sloan-Kettering Cancer Center
- Polish State Committee for Scientific Research [SPUBM-COPERNI-CUS/P-05/DZ-30/99/2000]
- Weston Park Hospital Charitable Trust
- European Commission (DG-XII) [IC15-CT96-0313]
- Radboud University Nijmegen Medical Centre
- [NIH K07 CA125203-01A2]
- [NIH R01CA060691]
- [NIH R01CA87895]
- [NIH N01-PC35145]
- [NIH P30CA22453]
- [NIH (NCI) RO1CA74386]
- [P50 CA090578]
- Grants-in-Aid for Scientific Research [21390190] Funding Source: KAKEN
Background and methods: Familial aggregation of lung cancer exists after accounting for cigarette smoking. However, the extent to which family history affects risk by smoking status, histology, relative type and ethnicity is not well described. This pooled analysis included 24 case-control studies in the International Lung Cancer Consortium. Each study collected age of onset/interview, gender, race/ethnicity, cigarette smoking, histology and first-degree family history of lung cancer. Data from 24,380 lung cancer cases and 23,305 healthy controls were analysed. Unconditional logistic regression models and generalised estimating equations were used to estimate odds ratios and 95% confidence intervals. Results: Individuals with a first-degree relative with lung cancer had a 1.51-fold increase in the risk of lung cancer, after adjustment for smoking and other potential confounders (95% CI: 1.39, 1.63). The association was strongest for those with a family history in a sibling, after adjustment (odds ratios (OR) = 1.82, 95% CI: 1.62, 2.05). No modifying effect by histologic type was found. Never smokers showed a lower association with positive familial history of lung cancer (OR = 1.25, 95% CI: 1.03, 1.52), slightly stronger for those with an affected sibling (OR = 1.44, 95% CI: 1.07, 1.93), after adjustment. Conclusions: The occurrence of lung cancer among never smokers and similar magnitudes of the effect of family history on lung cancer risk across histological types suggests familial aggregation of lung cancer is independent of those risks associated with cigarette smoking. While the role of genetic variation in the aetiology of lung cancer remains to be fully characterised, family history assessment is immediately available and those with a positive history represent a higher risk group. (c) 2012 Elsevier Ltd. All rights reserved.
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