期刊
ACS NANO
卷 9, 期 10, 页码 10268-10277出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.5b04243
关键词
photodynamic therapy; ratiometric biosensor; MMP-2 responsive; aggregation-induced emission; tumor
类别
资金
- National Natural Science Foundation of China [51125014, 51233003, 21474077]
- Ministry of Science and Technology of China [2011CB606202]
Photodynamic therapy faces the barrier of choosing the appropriate irradiation region and time. In this paper, a matrix metalloproteinase-2 (MMP-2) responsive ratiometric biosensor was designed and synthesized for aggregation-induced emission (AIE)-guided precise photodynamic therapy. It was found that the biosensor presented the MMP-2 responsive AIE behavior. Most importantly, it could accurately differentiate the tumor cells from the healthy cells by the fluorescence ratio between freed tetraphenylethylene and protoporphyrin IX (PpIX, internal reference). In vivo study demonstrated that the biosensor could preferentially accumulate in the tumor tissue with a relative long blood retention time. Note that the intrinsic fluorescence of PpIX and MMP-2-triggered AIE fluorescence provided a real-time feedback which guided precise photodynamic therapy in vivo efficiently. This strategy demonstrated here opens a window in the precise medicine, especially for phototherapy.
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