期刊
EUROPEAN JOURNAL OF CANCER
卷 47, 期 2, 页码 163-174出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2010.11.005
关键词
Core apoptosis; Cancer; miRNA; Chemoresistance
类别
资金
- FCT [SFRH/BD/21759/2005]
- FCT, Portugal
- European Social Fund
- Fundacao Calouste Gulbenkian
- FCT, the Portuguese Foundation for Science and Technology
Recent research has demonstrated that microRNAs (miRNAs) are key regulators of many cell processes often deregulated in cancer, including apoptosis. Indeed, it is becoming clear that many miRNAs are anti-apoptotic and mediate this effect by targeting pro-apoptotic mRNAs or positive regulators of pro-apoptotic mRNAs. Conversely, many pro-apoptotic miRNAs target anti-apoptotic mRNAs or their positive regulators. We have reviewed the current knowledge in this area including evidence of miRNA involvement in cancer drug resistance. (C) 2010 Elsevier Ltd. All rights reserved.
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