期刊
EUROPEAN JOURNAL OF CANCER
卷 47, 期 1, 页码 33-43出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2010.09.005
关键词
Leptin; Adiponectin; Ob-R; AdipoR1; AdipoR2; Leptin signalling; Adiponectin signalling; Breast cancer
类别
Obesity is associated with an increased risk of breast cancer in postmenopausal women. Accumulating evidence suggests that adipose tissue, which is an endocrine organ producing a large range of factors, may interfere with breast cancer development. Leptin and adiponectin are two major adipocyte-secreted hormones. The pro-carcinogenic effect of leptin and conversely, the anti-carcinogenic effect of adiponectin result from two main mechanisms: a modulation in the signalling pathways involved in proliferation process and a subtle regulation of the apoptotic response. This review provides insight into recent findings on the molecular mechanisms of leptin and adiponectin in mammary tumours, and discusses the potential interplay between these two adipokines in breast cancer. (C) 2010 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据