期刊
EUROPEAN JOURNAL OF CANCER
卷 46, 期 2, 页码 323-331出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2009.10.012
关键词
Parotid cancer; TNM classification; Tumour grading; Prognostic factor; Surgery
类别
Background: The tumour grading of primary parotid cancers (PPCs) remains controversial. Methods: A 20-year standardised single centre treatment has been assessed retrospectively The histological review of 155 consecutively treated parotid malignancies identified 96 suitable cases for univariate and multivariate survival analyses. Results: Treatment involved total parotidectomy, neck dissection and post-operative radiotherapy in, respectively, 91.7%, 83.3% and 70.4% of cases. The 5-year overall survival, disease-specific and recurrence-free survival rates were 79.4%, 83.5% and 70.8%, respectively. Univariate analysis confirmed the classical prognostic factors, i.e. age > 60 years, male gender, facial palsy, hardness of the tumour, clinical stage, tumour grade, facial nerve invasion and lymph node metastases. Multivariate analysis identified a three-grade classification just after the clinical stage as the most important prognostic factor. Conclusion: This study identifies the prognostic significance of intermediate grade tumours. (C) 2009 Elsevier Ltd. All rights reserved.
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