期刊
EUROPEAN JOURNAL OF CANCER
卷 45, 期 3, 页码 435-442出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2008.10.001
关键词
Breast cancer; Chromosomal instability; Prognosis; Single nucleotide polymorphism; Susceptibility
类别
资金
- European Union [LSHC-CT-2004-503465]
Chromosomal instability (CIN) is a major characteristic of many cancers. We investigated whether putatively functional single nucleotide polymorphisms (SNPs) in genes related to CIN (CENPF, ESPL1, NEK2, PTTG1, ZWILCH, ZWINT) affect breast cancer (BC) risk and clinical outcome in a Swedish cohort of 749 incident BC cases with detailed clinical data and up to 15 years of follow-up and 1493 matched controls. As a main observation, carriers of the A allele of the CENPF SNP rs438034 had a worse BC-specific survival compared to the wild type genotype GG carriers (hazard ratio (HR) 2.65, 95% confidence interval (CI) 1.19-5.90), although they were less likely to have regional lymph node metastases (odds ratio (OR) 0.71., 95% CI 0.51-1.01) and tumours; of stage II-IV (OR 0.73, 95% CI 0.54-0.99). As there is increasing evidence that CENPF is associated with poor prognosis in patients with primary BC, further independent studies are needed to clarify the importance of genetic variation in the CENPF gene in the clinic. (C) 2008 Elsevier Ltd. All rights reserved.
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