期刊
EUROPEAN JOURNAL OF CANCER
卷 45, 期 8, 页码 1352-1369出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2008.12.018
关键词
Nitric oxide; Tumour vasculature; Vasodilation; Cell respiration; Blood flow; Tumour oxygenation; Radiotherapy; Chemotherapy; Drug delivery; Imaging
类别
Hypoxia and blood flow heterogeneities are characteristics of solid tumours and are major obstacles for therapy. Exploiting the biology of nitric oxide (NO), a small radical with multiple functions, is particularly attractive to circumvent these sources of resistance and to sensitise tumour to cytotoxic treatments such as radiotherapy and chemotherapy. Indeed, while NO mediates angiogenic effects, NO may also promote tumour perfusion, drug delivery and oxygenation. Different strategies to deliver NO to tumours and pertaining to the FECS-EJC award laureate's work are reviewed, with a focus on their therapeutic potential. The development of techniques to monitor how and to which extent NO delivery influences the phenotype of a given tumour in a given patient is also discussed. (C) 2008 Elsevier Ltd. All rights reserved.
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