期刊
EUROPEAN JOURNAL OF CANCER
卷 44, 期 17, 页码 2608-2614出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2008.08.005
关键词
Cisplatin; Magnesium; Ovarian cancer; Renal function; Side effect
类别
资金
- Military Institute of The Health Services, Warsaw, Poland [WIM-1231/2004]
Background: The aim of this study was to examine the effect of magnesium supplementation on nephrotoxicity accompanying standard cisplatin-based chemotherapy in patients with epithelial ovarian cancer (EOC). Patients and methods: A double-blind, placebo-controlled, randomised study was conducted in which study arm magnesium sulphate (5 g) was administered before each course of standard chemotherapy with paclitaxel (135 mg/m(2)/24 h) plus cisplatin (7S mg/m(2)) every 3 weeks in patients with EOC. Magnesium subcarbonate (500 mg), three times per day orally, was administered during the treatment intervals. The control arm was administered a placebo instead of both magnesium salts. Magnesium serum levels (sMg) and GFR markers: serum levels of creatinine (sCr), Cockroft-Gault (CICG) and Modification Diet of Renal Disease (MDRD) formulae were recorded before each cycle, and 3 weeks after the sixth course. Results: 41 EOC patients were randomised and 40 were eligible. sMg varied significantly between the supplemented and placebo groups (p<0.0001). The control group showed a significantly greater decrease of GFR assessed by: sCr (p = 0.0069), CICG (p = 0.0077) and MDRD (p = 0.032) formulae compared with the magnesium supplemented group. Conclusions: These results demonstrate the nephroprotective effect of magnesium supplementation during chemotherapy with cisplatin. (C) 2008 Elsevier Ltd. All rights reserved.
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